Who should not take Menopause Hormone Therapy (MHT)?

Published on January 30, 2026

3 minutes

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What you’ll learn

We’ll explain the difference between HRT and MHT, break down situations where MHT can offer relief, and help you understand how your health history affects your options.

Hot flashes. Brain fog. Weight gain. Mood swings. Night sweats. If you’re sweating through your clothes, leaving your phone in the fridge, or not on speaking terms with your scale, menopause hormone therapy (MHT) might seem like the obvious answer. 

MHT can be a game-changer for many women and help them feel more like themselves instead of just powering through menopause and perimenopause. However, understanding if MHT is right for you doesn’t just depend on your symptoms, but also hinges on an honest discussion with your doctor about your personal health history. 

Who isn’t a good candidate for hormone replacement therapy (HRT) / menopause hormone therapy (MHT)?

While menopause hormone therapy (MHT) can bring life-changing relief to many women, it’s not right for everyone. You may have seen this treatment called HRT (hormone replacement therapy), but doctors have moved away from that because the term “replacement” suggests something is wrong and needs to be fixed. MHT has been chosen as a better fit because menopause is a normal stage of life, and this therapy is about managing symptoms through individualized care. 

Dr. Sheryl Ross (Dr. Sherry), Chief Medical Officer of Women’s Health at QuickMD, says that women with the following health histories should avoid MHT:

  • Personal history of breast, ovarian or endometrial cancer 
  • Strong family history of breast cancer
  • History of blood clots, stroke, or heart disease 
  • Liver disease (active or severe)
  • Untreated high blood pressure
  • Abnormal vaginal bleeding
  • Pregnancy or plans to become pregnant

If you fall into one of these categories, it doesn’t mean you’re stuck dealing with severe symptoms. Your doctor can work with you to explore alternative treatments like Selective Serotonin Reuptake Inhibitors (SSRIs) for hot flashes or exercise for mood and bone health.

Who can benefit from menopause hormone therapy (MHT)?

For many women, menopause hormone therapy is safe and can ease the frustrating symptoms that disrupt life the most. MHT can be systemic, meaning it treats the entire body, or local, meaning it targets a specific area.

If you start MHT before age 60 or within 10 years of menopause, the benefits may outweigh the risks. If you’re thinking about MHT, you may especially benefit from it if you:

  • Struggle with hot flashes: Hot flashes hijack moments in your day, but systemic MHT is the most effective treatment available compared to lifestyle changes and non-hormonal prescription drugs.
  • Feel exhausted from poor sleep: Losing sleep night after night is nothing short of a waking nightmare. Systemic MHT relieves night sweats, which can improve overall sleep quality.
  • Have vaginal dryness: Dryness can interfere with your sex life and overall comfort. Local MHT creams, tablets, or rings can help restore moisture and ease discomfort.
  • Feel the haze of brain fog: Brain fog often gets overlooked, but systemic MHT can help clear it by reducing hot flashes and improving sleep quality.
  • Experience mood changes: Irritability, anxiety, and depression can stem from fluctuating hormone levels and poor sleep. Systemic MHT helps stabilize hormones, which stabilizes mood. 
  • Need support for bone health: Estrogen protects bones and prevents bone loss, so lower levels during menopause increase the risk of osteoporosis. Systemic MHT is proven to be highly effective in preserving bone health. 
  • Have early menopause: If you’ve had your ovaries removed or are going through early menopause, MHT can help lower your risk for conditions such as osteoporosis and heart disease. 

Let’s discuss whether you’re a candidate for MHT

Think MHT might be right for you? Here at QuickMD, our team of doctors understands women’s health and menopause care. We can help you determine if MHT is right for you. Even if you saw yourself in one of the conditions Dr. Sherry mentioned, that doesn’t mean you’re out of options. There may be alternative treatments or specific circumstances where MHT could still work for you. 

Book a visit to find out what’s possible.

We can walk you through your options, answer your questions, and create a treatment plan that fits your symptoms and health history.

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Frequently asked questions

Can you take MHT with high blood pressure?

Having high blood pressure doesn’t automatically rule out MHT for you, but it should be controlled before starting. This means your blood pressure is consistently under control with or without medication and monitored regularly. Your provider may recommend a low-dose, non-oral MHT option such as a patch or gel because it has less impact on blood pressure and cardiovascular risk. Your provider can help you weigh the risks and benefits based on your specific situation.

Can smokers take MHT?

While smoking doesn’t exclude you from using MHT, it does raise your risk of heart disease, stroke, and blood clots. Your provider may recommend a transdermal patch or gel and advise you to quit smoking to reduce your overall risk. If you’re ready to quit, your provider can connect you with resources to help.

Disclaimer

Articles on this website are meant for educational purposes only and are not intended to replace professional medical advice, diagnosis or treatment. Do not delay care because of the content on this site. If you think you are experiencing a medical emergency, please call your doctor immediately or call 911 (if within the United States). This blog and its content are the intellectual property of QuickMD LLC and may not be copied or used without permission.

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