Published: June 5, 2024

Clostridium Difficile Infection: Which Antibiotics Carry the Highest Risk of C. Diff?

Written by QuickMD Publications Team

2 minutes

Man with c. diff

Clostridium difficile (C. diff) is a bacterium that can cause colitis, an inflammation of the colon. This bacterium is naturally found in the colon, where it is usually kept in check by other bacteria. However, it can overgrow when the “good bacteria” in the intestines die off, often due to antibiotic use.

This can lead to symptoms such as abdominal pain and diarrhea.

Antibiotics with the Highest Risk of Causing C. Diff Infections

Certain antibiotics are more likely to disrupt the balance of bacteria in the intestines, leading to a higher risk of C. diff infections.

These include the following.

Cephalosporins (especially second and third-generation):

  • Lorabid (loracarbef)
  • Cefotan (cefotetan)
  • Zinacef (cefuroxime)
  • Ceftin (cefuroxime)
  • Cefzil (cefprozil)
  • Mefoxin (cefoxitin)
  • Omnicef (cefdinir)
  • Spectracef (cefditoren)
  • Suprax (cefixime)
  • Claforan (cefotaxime)
  • Fortaz (ceftazidime)
  • Cedax (ceftibuten)

Other high-risk antibiotics:

  • Cleocin (clindamycin)
  • Amoxil (amoxicillin)
  • Omnipen, Ampi (ampicillin)

Prevention of C. Difficile Infections

Remember, the most effective way to prevent C. diff infections is by avoiding unnecessary antibiotics. Your doctor’s decision not to prescribe antibiotics for certain conditions is often a precaution to prevent potential harm and avoid antibiotic resistance, ensuring your safety.

Treatment of C. Difficile Infections

When C. difficile colitis develops, it is treated with another antibiotic:

  • Vancocin (vancomycin): Taken orally at a dose of 125 mg four times a day for ten days.
  • Flagyl (metronidazole): Taken orally at a dose of 250 mg four times a day or 500 mg three times a day for ten days.

Did you know? QuickMD can diagnose and treat C. difficile infections remotely through telemedicine. Our process involves a thorough review of your symptoms and medical history, followed by a virtual consultation with a qualified healthcare professional.

If necessary, we can provide appropriate prescriptions, all from the comfort and safety of your home.

Disclaimer

Articles on this website are meant for educational purposes only and are not intended to replace professional medical advice, diagnosis or treatment. Do not delay care because of the content on this site. If you think you are experiencing a medical emergency, please call your doctor immediately or call 911 (if within the United States). This blog and its content are the intellectual property of QuickMD LLC and may not be copied or used without permission.

QuickMD has strict referencing policies and relies on reputable sources, including peer-reviewed research, clinical guidelines, medical organizations, and government and public health agencies, among others. Learn more about how we ensure accuracy in our content by reading our editorial guidelines.

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