Estradiol and norethindrone (generic Activella)
Hello, protection! Estradiol and norethindrone tablets work together to balance hormones caused by menopause, ease disruptive symptoms, and safeguard long-term health.
Improves mood swings, sleep, brain fog, and vaginal dryness
Oral combination hormone therapy
Just $34 per month with your membership
Speak with a doctor and unlock exclusive pricing with a Menopause Hormone Therapy Membership
Get your first month free!*
*A QuickMD doctor can prescribe medication only after your visit, and prescriptions aren’t guaranteed. The listed price covers medication only and doesn’t include the membership fee. Your MHT Membership gives you access to your doctor visit, ongoing support, and related care services. The first month is free, then renews at $79/month. You can cancel anytime.
Start hormone therapy
Perimenopause and menopause symptom relief. No insurance required.
Medication price for members:
Unlock exclusive pricing on medications when prescribed and filled through QuickMD by booking a visit to start your Menopause Hormone Therapy Membership.
Membership includes:
Same-day visits with an actual doctor
Get medications delivered directly to you
Get fast answers from our care team
Getting started with Estradiol and norethindrone at QuickMD
Description
Estradiol and norethindrone tablets are a prescription medication that combine two essential hormones your body naturally produces. Together, they help restore hormone balance, ease perimenopause and menopause symptoms such as hot flashes, night sweats, sleep disturbances, and mood changes, and support vaginal and bone health. The addition of progesterone also protects the uterus from abnormal tissue growth. Estradiol and norethindrone tablets may also be prescribed for women whose bodies do not make enough of these hormones on their own. You can meet with a QuickMD doctor to see if estrogen and progesterone tablets are the right option for you.
How to use
Take estradiol and norethindrone tablets exactly as directed by your QuickMD doctor. Swallow one tablet by mouth each day with a glass of water, at the same time each day. You may take it with or without food. Do not take more often than directed. Taking your medication consistently helps keep hormone levels steady and treatment effective. Each prescription comes with a patient information leaflet. Be sure to read it carefully, and ask your doctor if you have any questions.
Benefits
- Reduces the risk of endometrial hyperplasia
- Supports bone strength and long-term skeletal health
- Protects the uterus with added progesterone
- Helps ease hot flashes and night sweats during menopause
- May improve mood stability and reduce irritability
- Supports vaginal comfort and reduces dryness
- Promotes better sleep quality and nighttime rest
- Simple, once-daily tablet
Side effects
Serious or adverse side effects from estradiol and norethindrone tablets are rare. However, some women may experience mild nausea, breast tenderness, bloating, or headaches when starting treatment. Spotting or light bleeding can also occur during the first few months of starting treatment. Less commonly, fluid retention, mood changes, or weight fluctuations may happen.
This is not a full list of side effects, interactions, or warnings, and it should not replace medical advice. For guidance tailored to your health and medications, always talk with your healthcare provider or pharmacist.
Safety information
Estradiol and norethindrone must be prescribed by a licensed doctor. A consultation with a QuickMD doctor is required to review your health and determine if this prescription medication is appropriate for you.
Frequently asked questions
How much do estradiol and norethindrone tablets cost?
Estradiol and norethindrone tablets are $34 with QuickMD’s cash-pay option, giving you clear, upfront pricing with no hidden fees. Many women prefer this route because it’s simple, stress-free, and allows their medication to be shipped right to their door.
If you’d rather use insurance, your doctor can send your prescription to your local pharmacy. Costs and coverage depend on your plan, but your QuickMD doctor will walk you through the options so you can choose what works best for your health, your budget, and your life.
Do estradiol and norethindrone cause weight gain?
Some women notice small changes in weight or fluid retention when starting estradiol and norethindrone, while others do not. These shifts are usually mild and may improve as your body adjusts. If you’re concerned about weight changes, your QuickMD doctor can talk through what’s normal, what to watch for, and ways to support your overall well-being while on treatment.
What is the difference between estradiol and norethindrone?
Estradiol is a form of estrogen, the hormone that helps relieve menopause symptoms like hot flashes, night sweats, and vaginal dryness. Norethindrone is a form of progesterone, which balances estrogen and protects the lining of the uterus. Together, they work as a team to ease symptoms while helping keep your uterus healthy.
How the membership works
Book your first visit. It’s free to start!
To begin your MHT Membership, book your first visit with a QuickMD doctor who understands perimenopause and menopause. Start with your first month free, then continue at $79 per month, which includes a doctor’s visit, your prescription, and ongoing care. During your first appointment, your doctor will review your health history, listen to your symptoms, and answer your questions. Together, you’ll decide whether hormone therapy feels right for you and start care that’s supportive, personal, and focused on lasting relief.
Unlock the perks of woman-centered care
Your membership gives you immediate access to answers when you need them most. Each month, your first doctor’s visit is included in your membership, and if you need additional support, extra visits are just $49. If medication could help ease your symptoms, your doctor will take the time to discuss your options and prescribe what you need during your visit. You can choose to have it shipped directly to your home with transparent pricing, or sent same-day to your local pharmacy. There are no contracts to lock you in, so you can cancel anytime. It’s flexible care built around what you’re going through, so you get the care you deserve.
Find relief with Estradiol and norethindrone, if right for you
If your doctor determines estradiol and norethindrone tablets are right for you, they can prescribe them as part of your treatment plan. By restoring both estrogen and progesterone, this medication helps your body regain balance over time. As hormone levels begin to stabilize, many women notice relief from hot flashes, night sweats, and sleep disturbances, along with essential uterine protection. Mood often improves, focus becomes sharper, and vaginal comfort returns as therapy continues. While these changes take time, regular check-ins with your doctor through your membership ensure your dose and treatment plan are safe and effective for you.
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Helpful reading about hormone therapy
