Tirzepatide price guide: cost of Zepbound® and Mounjaro® with and without insurance

You’ve probably seen a lot of news stories and commercials about people finding success with prescription medications as part of their weight loss journey. For many, these medications have helped them see real progress. 

While GLP-1s like Ozempic® are some of the most popular names, tirzepatide medications (including name brands like Zepbound® and Mounjaro®) can also provide great results, especially when paired with a diet and exercise program. 

Tirzepatides are injectable, prescription-only medications that can improve blood sugar in adults. While insurance plans may cover Zepbound or Mounjaro for some individuals, paying entirely out of pocket can cost around $12,000 or more per year. 

If you’re considering taking Zepbound or Mounjaro and have insurance, find out if the medication is covered by your plan for your specific needs. And if your plan doesn’t cover a prescription, we’ll help you discover how to access these life-changing medications at a lower cost. 

What is tirzepatide?

Tirzepatide is the active ingredient in name-brand medications like Zepbound and Mounjaro. It works by activating receptors in the body for two hormones, GIP and GLP-1. Tirzepatide mimics these hormones to regulate blood sugar levels and decrease appetite. Although it was originally FDA-approved to treat type 2 diabetes, tirzepatide has also been prescribed off-label to support weight loss efforts. 

Why are patients excited about tirzepatide?

Tirzepatide is a dual-action medication that targets two metabolic pathways: GIP and GLP-1 receptors. This unique dual approach makes tirzepatide effective in managing weight for a few key reasons. 

• It helps suppress appetite: When tirzepatide targets GLP-1 receptors, the medication reduces cravings and helps you feel full for longer. It regulates blood sugar by encouraging insulin production and signaling to your brain that you’re full. 
• It helps improve metabolism: When tirzepatide targets GIP receptors, it promotes better blood sugar control and helps your body more effectively metabolize fats and store energy.
  

In fact, clinical results for tirzepatide-based medications show that they’ve contributed to significant weight loss. In a recent study conducted by the New England Journal of Medicine, participants lost an average of 15% of their body weight over a 72-week period on a weekly 5 mg dose of tirzepatide. Participants who took a 10 mg dose over the same period lost close to 20% of their body weight.

Factors influencing the cost of Zepbound and Mounjaro

Several factors can affect what you’ll pay for tirzepatide medications like Zepbound and Mounjaro. Understanding these elements can help you plan your treatment budget more effectively.

• Dosage and duration: Higher doses typically cost more, and longer treatment periods increase overall expenses. For instance, a 28-day prescription for Zepbound at a 7.5 mg dose can run $599 at retail cost, compared to $1,049 for a 28-day supply of a 15 mg dose. Many patients start on lower doses and work up to maintenance levels over time. Getting a three-month supply instead of monthly refills can sometimes lower costs if your insurance allows it.
• Insurance coverage: Insurance often treats diabetes treatment (Mounjaro) differently from weight management (Zepbound). Some plans cover one use but not the other, so your specific diagnosis can impact what you’ll pay out of pocket.
• Pharmacy pricing: Prices can vary greatly between different pharmacies. Shopping around at local pharmacies and checking larger chains might help you find better pricing. 
• Manufacturer discounts: Taking advantage of savings programs and discount cards can significantly reduce costs. Eli Lilly (maker of Zepbound and Mounjaro) offers savings cards that can lower costs significantly for eligible patients. These programs often lower monthly costs to $25 or less for those with commercial insurance. Patients without insurance may qualify for different assistance programs based on financial need.
• Medicare and Medicaid changes: Starting in 2026, new Medicare programs may offer coverage with lower copays for eligible patients. Medicaid coverage varies by state, with some states covering these medications while others don’t. Recent policy changes are creating new pathways for coverage, though availability depends on your specific plan and location.

How much do Zepbound and Mounjaro cost without insurance?

For those paying out of pocket, understanding the typical price ranges can help with planning and making a choice that feels right to you and your doctor. While retail costs can be pricey, manufacturer savings programs offer more affordable pathways for many patients. Here’s a breakdown of current pricing for both medications:

How much do Zepbound and Mounjaro cost with insurance?

With insurance coverage, the cost of tirzepatide medications like Zepbound and Mounjaro becomes much more manageable for most patients. The final price you’ll pay depends entirely on your specific health insurance plan details, including 

• Your deductible status.
• Your copay, a fixed dollar amount you pay for a prescription after you meet your deductible. 
• Whether your plan covers these medications at all.
  

Beyond your insurance plan details, there are several other key factors that determine your out-of-pocket costs:

• Your plan’s formulary tier determines whether the medication is covered and at what copay level.
• Prior authorization requirements may need to be met before coverage begins.
• Your deductible status affects whether you pay the full price or just a copay.
• Diagnosis matters because insurance plans often categorize medications based on what they’re treating. Many plans cover Mounjaro as an FDA-approved medication for diabetes management, but may have different rules or exclude Zepbound for weight management, even though both contain the same active ingredient.
• Manufacturer savings cards can further reduce costs for eligible commercially insured patients.
  

These factors combined can greatly affect how much you’ll pay for your medication with insurance. Below are typical cost ranges for patients with insurance coverage:

Ways to save money on your tirzepatide medication

Previously, supply challenges caused a shortage of brand-name tirzepatides and GLP-1s. As a result, the FDA allowed compounding pharmacies to make their own versions of these medications. Compounded versions offered a less expensive, generic alternative. In 2025, the medication shortage ended, and the FDA phased out compounded tirzepatide. While this means one affordability option is no longer available, patients still have a few ways to access Zepbound and Mounjaro at lower costs. 

1. Explore telemedicine options. With platforms like QuickMD, you’ll visit with a doctor who’ll work with you to better understand your weight loss goals. If appropriate, they’ll prescribe Zepbound, Mounjaro, or another medication that works for your unique needs. Virtual appointments are just $99 per visit, and your doctor can send your tirzepatide prescription to your pharmacy of choice to help you get the best price. 
2. Check for patient assistance programs. Zepbound and Mounjaro manufacturer Eli Lilly offers savings programs that can significantly reduce costs for patients who qualify. 
3. Compare pharmacies. From your local corner drugstore to nationwide chains, prices on medication can vary significantly. For instance, Walmart offers in-store pickup for Zepbound starting at $349. You can also check websites like GoodRx.com or TrumpRx.gov to compare prices. Shopping around for the best deal can make a big difference.

Why choose QuickMD for your tirzepatide medication?

At QuickMD, we believe getting the right medication shouldn’t be complicated or stressful. We make it easy for you to get your Mounjaro or Zepbound prescription. Whether you’re just starting your weight loss journey or continuing treatment, our process is made to be straightforward and supportive.

With just a quick phone or video consultation, you’ll meet with a doctor who can evaluate your needs and listen to your concerns. If appropriate, they’ll prescribe tirzepatide or another medication for you, then send your prescription directly to your pharmacy. We’re here to make managing your health convenient, accessible, and affordable, so you can focus on your goals without added stress. 

Benefits of choosing QuickMD:

• Daily availability, including weekends: Get help when you need it from the comfort of home. No waiting in a doctor’s office or shuffling your schedule. 
• On-demand or same-day appointments: Skip the weeks-long wait times. Same-day appointments are available to help you get started on your weight loss journey. 
• Experienced doctors: You’ll meet with doctors who understand weight management medications and can answer your questions to create a custom plan that works for you. 
• Affordable care: Get access to high-quality, personalized healthcare without the high costs. Virtual visits cost just $99 per session. 

How to get started with Mounjaro and Zepbound at QuickMD

1. Schedule a consultation: Visit QuickMD’s Weight Loss Services to book an appointment. All it takes is just a few minutes. 
2. Meet with your doctor: You’ll discuss your weight loss goals and medical history with a doctor, all from the comfort of home, all without judgment. 
3. Receive your prescription: Get your Zepbound or Mounjaro prescription sent directly to your preferred pharmacy, ready for pickup.